產品中心
產品詳情

  • 產品名稱：IRAK1BP1抗原（重組蛋白）

  • 產品型號：1mg
  • 產品廠商：通蔚生物
  • 產品價格：3580
  • 產品庫存：35
  • 產品文檔：
你添加了1件商品 查看購物車
簡單介紹：
我司專業(yè)生產經(jīng)銷生命科學領域的知名 IRAK1BP1抗原（重組蛋白）等相關產品，產品保證上等，種類齊全及充足的貨源，為顧客提供更多的選擇.期待您的來電! 對客戶我們應做到誠實守信，合作共贏，實現(xiàn)對客戶需求的完全保障以及上等的服務體系。
詳情介紹：

中文名稱： IRAK1BP1抗原（重組蛋白）

英文名稱： IRAK1BP1 Antigen (Recombinant Protein)

別     名：  AIP70; SIMPL

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述

Full length fusion protein

技術規(guī)格

Full name:

interleukin-1 receptor-associated kinase 1 binding protein 1

Synonyms:

AIP70; SIMPL

Swissprot:

Q5VVH5

Gene Accession:

BC112253

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.





姓名：
電話：
您的需求：