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  • 產(chǎn)品名稱(chēng)：ABL1抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：1mg
  • 產(chǎn)品廠(chǎng)商：通蔚生物
  • 產(chǎn)品價(jià)格：3580
  • 產(chǎn)品庫(kù)存：35
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中文名稱(chēng)： ABL1抗原（重組蛋白）

英文名稱(chēng)： ABL1 Antigen (Recombinant Protein)

儲(chǔ)     存：  冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概     述

Fusion protein corresponding to a region derived from C terminal 250 amino acids of human ABL1

技術(shù)規(guī)格

Full name:

c-abl oncogene 1, non-receptor tyrosine kinase

Synonyms:

ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl

Swissprot:

P00519

Gene Accession:

BC117451

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.







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